Cheap Flights from Des Moines to Santa Ana John Wayne

Compare Des Moines to Santa Ana John Wayne flight deals

Find the cheapest month or even day of the year to fly to Santa Ana John Wayne

Book the best Santa Ana John Wayne fare with no extra fees

Flight deals from Des Moines Airport to Santa Ana John Wayne Airport

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to Santa Ana John Wayne Airport? If you want to travel next month, return fares start from £164. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Des Moines to Santa Ana John Wayne

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Santa Ana John Wayne flights are currently cheapest in February.

Direct flights from Des Moines to Santa Ana John Wayne

Des Moines to Santa Ana: Flight information

The things to know before you go.
Cheapest flight found£51
Cheapest month to flyFebruary
Average flight time3 hrs, 49 mins
Most popular airlineAllegiant Air
Average flights per week3

Finding cheap flights from Des Moines to Santa Ana John Wayne: Frequently asked questions

The best price we found for a return flight from Des Moines to Santa Ana John Wayne is £91. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
3 hours and 49 minutes is the average flight time from Des Moines to Santa Ana John Wayne.
Allegiant Air flies direct from Des Moines to Santa Ana John Wayne.
As of January 2026, there are 3 flights per week flying from Des Moines to Santa Ana John Wayne.
The cheapest month to fly from Des Moines to Santa Ana John Wayne is usually February.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Santa Ana John Wayne Airport on Monday, 16 February 2026.
Yes – the average flight time is 3 hours and 49 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santa Ana John Wayne but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santa Ana is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Allegiant Air offers the cheapest flight tickets to Santa Ana John Wayne.

How to find cheap flights to Santa Ana John Wayne from Des Moines

Looking for cheap tickets from Des Moines to Santa Ana John Wayne? Here are a few tips on how to secure the best flight price and make your journey as smooth as possible.

  • Simply hit 'search'. From British Airways to international carriers like Emirates, we compare all major airlines along with the most popular online travel agents to find the cheapest plane tickets from Des Moines to Santa Ana John Wayne. And with us there are no hidden fees - what you see is what you pay.
  • Compare flight deals to Santa Ana John Wayne from Des Moines from over 1,000 providers. Then choose the cheapest or fastest plane tickets.
  • Flex your dates to find the best Des Moines-Santa Ana John Wayne ticket prices. If you are flexible when it comes to your travel dates, use Skyscanner's 'Whole month' tool to find the cheapest month, and even day to fly to Santa Ana John Wayne from Des Moines.
  • Set up a Price Alert. You can easily track the fare of your cheap Des Moines-Santa Ana John Wayne flights by creating an alert. Whenever prices go down or up, you'll get an email or push notification to help make sure you get the best possible flight deal.
  • Fly without stops. Only interested in direct flights between Des Moines and Santa Ana John Wayne? Make sure to tick 'Direct flights only' when performing a search. If there are direct flights available on the route, these will appear in the results.
  • Find the cheapest Business class flights from Des Moines and Santa Ana John Wayne. We scour the internet for the best Business, Premium Economy and First Class flight fares to Santa Ana John Wayne, too. Check the difference in price as you search – you might just chance upon a last-minute low fare. Note that not all cabin classes are available for every destination or airline.
  • Include nearby airports in your search. Widen your search for Des Moines to Santa Ana John Wayne flight deals by selecting the "add nearby airports" option. This will allow you to see flight prices for all the nearest airports at your departure point and your destination and could help you save next time you travel.
  • Combine your flight to Santa Ana John Wayne from Des Moines with hotels and car hire

    Once you've secured your cheap flight ticket from Des Moines to Santa Ana John Wayne, discover the best prices and exclusive rates for hotels in Santa Ana John Wayne or nearby. You can also compare hundreds of car hire companies in one go so that you get the best car hire price for your trip.


Prices shown on this page are estimated lowest prices only. Found in the last 45 days.